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Cortisol Saliva Test - 4 Specimens

  • CLIA Certified Labs
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This test provides measurements of cortisol levels across four saliva samples.

  • Sample Type: Saliva
  • Results: 6-11 days
  • Age: 18+

The Cortisol 4 Point Saliva, 4 Samples test is a diagnostic test that measures cortisol levels at four specific times throughout the day using saliva samples. Cortisol is a hormone produced by the adrenal glands that plays a crucial role in the body's stress response, metabolism, immune function, and maintaining blood pressure. This test is ordered to assess the diurnal variation of cortisol levels, which refers to the natural fluctuation of cortisol levels throughout the day.

People ordering this test must acquire a specimen collection kit at the lab prior to making a collection. Saliva should be collected at the time(s) prescribed by your doctor. No food or fluids for 30 minutes prior to collection. Do not use any creams, lotions, or steroid inhalers immediately prior to collection. Avoid any activity that can cause your gums to bleed, including brushing and flossing your teeth. Consult with your doctor if this is a chronic problem. Do not use this kit on anyone with increased risk of swallowing or choking.

Quest test codes: 18921


+$15 service fee

Price does not include the Physician Service Fee ($6) and the Lab Collection Fee ($9). These non-refundable fees cover the ordering and oversight of lab tests and follow-up services when appropriate.

Next availability

Provided by Quest Diagnostics


4.6 rating

How does it work?

  • Order Tests Online

    No doctor visit required for purchase. Choose from a wide range of panels and tests. Pay online with a credit or debit card — no insurance needed.
  • Go to the Lab for Sample Collection

    Complete your test sample collection during your scheduled appointment.
  • Get Fast Results Online

    We will email you when your results are ready. Access your Confidential Lab Record by logging in to your account. There you can view, save and print your results.

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Frequently Asked Questions

Your provider may order this test to diagnose disorders of the adrenal and pituitary glands. These include Cushing’s syndrome, Addison’s disease, Adrenocortical Insufficiency, or Hypersecretion.

Your provider may wish to order a Cortisol Saliva Test if you’ve exhibited symptoms related to irregular cortisol production, such as: 

  • unexplained weight loss or gain
  • anxiety
  • chronic fatigue
  • muscle weakness
  • abdominal pain
  • skin that bruises easily
  • very high or low blood pressure 

You must follow the collection kit directions very closely to take the Cortisol Saliva Test at home. 

Once you receive the results of your test, you will need to consult with your provider. Only a medical professional can advise you on the healthy ranges of cortisol in your body and help you develop a treatment plan if necessary. You can get an online consultation with a vetted, highly rated doctor through Tripment Health. 

Normal aging is associated with cortisol changes, including changes in the structure and function of the adrenal gland. Infection, stress, pregnancy, birth control pills, and other medicines can also affect cortisol levels.

To prepare for a Cortisol Saliva Test, your provider will issue a specimen container and specific collection instructions. They may ask you to not eat, drink, or brush your teeth 30 minutes prior to collection. Because cortisol levels change throughout the day, your provider will likely recommend that your test be conducted at a specific time when cortisol levels are lower. Cortisol Saliva Tests are considered to be highly accurate, though they may be used in conjunction with additional blood, urine, or imaging tests, such as CT scans and MRIs, for an even deeper analysis. Cortisol Saliva Test results typically take 4-9 business days to process. 

The cost of a Cortisol Saliva Test listed on Tripment Health is transparent and final – you will never be asked to pay additional fees at the testing facility, or receive a surprise bill down the road. 

Tripment Health has partnered with nearly 7,000 lab test facilities across 48 states. Finding a Cortisol Saliva Test, current procedural technology (cpt) code 18921, is easier than ever. Add the lab tests you need to your cart, then select a testing facility conveniently close to you.