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Human Epididymis Protein 4 (HE4) test

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HE4 is a common tumor marker for ovarian cancer. It can also be used to monitor how well a person is responding to treatment.

The Human Epididymis Protein 4 (HE4) Test works as a tumor marker for ovarian cancer. In some cases, it can also be used to monitor how well a person responds to treatment.

What is a Human Epididymis Protein 4 (HE4) Test?

A Human Epididymis Protein 4 (HE4) Blood Test measures levels of human epididymis protein 4 (HE4) in the blood. HE4 is produced by epithelial ovarian cancer cells, and is used as a marker for both ovarian and endometrial cancers. Epithelial ovarian cells are the cells that develop in the lining that surrounds the ovaries — about 90% of ovarian cancer cases are epithelial cancer.

Why would my doctor order a Human Epididymis Protein 4 (HE4) test?

Your provider may order this test to monitor epithelial ovarian cancer after treatment, to detect recurrence and disease progression, or to help determine an appropriate treatment plan. The HE4 test is not used for screening for cancer, since there are other types of cells in the body that also produce HE4. Presence of HE4 alone is not enough to diagnose cancer.

When should I order a Human Epididymis Protein 4 (HE4) Test?

You may wish to order a Human Epididymis Protein 4 (HE4) test if you’ve already been diagnosed with ovarian cancer, to monitor progression or response to treatment. 

You cannot take a Human Epididymis Protein 4 (HE4) Test at home — this test can only be administered by a medical professional at a licensed testing facility. 

How do I read the results of the test?

Once you receive your HE4 blood test results, you will need to consult with your provider. Only a medical professional can advise you on the results of your HE4 levels, help you determine whether or not your HE4 levels are in the normal range, and help you develop a treatment plan if necessary. 

Do my results change with age?

A person’s risk of developing ovarian cancer increases with age. About 90% of women who are diagnosed with ovarian cancer are over 40 — most are women aged 60 or older. However, having a family history of breast or ovarian cancer can increase your risk of developing these diseases at a younger age.

What should I expect at my appointment?

To prepare for a Human Epididymis Protein 4 (HE4) Test, your provider will draw a blood sample from a vein in your arm. HE4 tests are considered to be highly accurate, though they may be ordered along with a CA 15-3 lab test or other clinical evaluations for an even deeper analysis. HE4 test results typically take 3-7 business days to process. 

How much does a test cost?

The cost of a Human Epididymis Protein 4 (HE4) Test listed on Tripment Health is transparent and final – you will never be asked to pay additional fees at the testing facility, or receive a surprise bill down the road. 

Where do I find an affordable Human Epididymis Protein 4 (HE4) Test near me?

Tripment Health has partnered with nearly 7,000 lab test facilities across 48 states. Finding a Human Epididymis Protein 4 (HE4) Test, current procedural technology (cpt) code 16500, is easier than ever. Add the lab tests you need to your cart, then select a testing facility conveniently close to you. 


Does taking Biotin supplements affect HE4 test results? 

Taking Biotin supplements can affect the results of a wide range of lab tests, including an HE4 test. Before you take this test, discuss with your doctor how Biotin can influence HE4 levels. 

What is considered a high number for HE4 blood test results?

These numbers, and what they mean, can vary from patient to patient. It is important to have your results interpreted by a licensed medical professional who can provide a proper diagnosis based on more than one factor. 


+$15 service fee

Price not includes a Physician Service Fee ($6) and a Lab Collection Fee ($9). These non-refundable fees cover the ordering and oversight of lab tests, and follow-up services when appropriate.

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Lab tests FAQs

No. At Tripment Health, we focus on providing transparent healthcare services to uninsured or under-insured individuals. We’ve negotiated prices directly with lab test facilities to make diagnostic lab panels available to individuals who would rather pay directly than go through a private or government-sponsored insurance carrier.

No. By purchasing a blood panel, you will not be able to submit any claim, bill, or other request for reimbursement to any insurer, third-party payer, or Government health program. However, you can use your FSA or HSA card.

You will receive a payment confirmation email, then an additional email confirming your appointment details (type of test, time and location of appointment, and QR code). You will need to present your QR code to the testing facility in order to check in.

Once your test is complete, you will receive your results within 1-3 business days.

With a blood panel, you can establish your body’s baseline values for basic health measurements like cholesterol (total, triglycerides, HDL, LDL and total cholesterol/HDL ratio), glucose and hemoglobin A1c. Additionally, depending on the blood panel you choose, you will receive data on performance measurements such as Vitamin D, Vitamin B12, Magnesium, Thyroid Stimulating Hormone, and/or Testosterone.


Your results are more than just numbers. Your results come with a personalized recommendation from one of our physicians.

No. One of our physicians will order the panels for you.

You must be 18 or over to be able to get tested.

Currently we have local patient service centers available in all states, except in NY, NJ, TX & RI.